Statistical analysis
We used the Student’s t-test for the analysis of continuous variables, and the chi-square test or Fisher’s exact test for the analysis of categorical variables. To determine the signal intensity distribution of the aptamer-based assay according to the severity of PE, a linear-by-linear association was used. The Wilson interval method was used to evaluate the following: diagnostic performance, sensitivity and specificity, positive and negative predictive values, and positive and negative likelihood ratios with 95% confidence intervals. AP -value of <.05 was considered statistically significant. IBM® SPSS® Statistics version 25.0 software (IBM® Inc., Armonk, NY) was used for the analyses.
This study was supported by the Seoul National University Bundang Hospital Research Fund [grant number 06-2019-198].