What is already known?
1. MDP is a derivative of paeoniflorin and could inhibit inflammatory
responses.
2. Activated HSCs played a crucial role in the development of liver
fibrosis, and miRNA could regulate the HSCs activation and
proliferation.
3. In the senescence stage, activated HSCs can reduce the expression of
ECM and increase the expression of ECM degrading enzymes while
inhibiting cell proliferation.