PLSCR1 expression is decreased in mouse lungs after H1N1 SIV infection
PLSCR1 is a calcium ion-binding type II membrane protein, and is highly conserved among different species including human and pigs (Figure 1A). SIV(QD-2018 strain) is a type H1N1 IAV strain isolated from pigs in Shandong province of China(Yu ,2020). This strain has very high homology with human influenza virus isolated in 2009, with the identity of the NP higher than 98.6% (Figure 1B). This conservation allows us to use SIV in our following investigation of the IAV-associated disease.