SCREENING OF CHO-K1 ENDOGENOUS PROMOTERS FOR EXPRESSING RECOMBINANT PROTEINS IN MAMMALIAN CELL CULTURES
Ileana Tossolini1,a,b, Agustina Gugliotta1,a, Fernando López Díaz4, Ricardo Kratje1, Claudio Prieto2,3
1 UNL, CONICET, FBCB (School of Biochemistry and Biological Sciences), CBL (Biotechnological Center of Litoral), Ciudad Universitaria, Ruta Nacional 168 Km 472.4, C.C. 242. (S3000ZAA), Santa Fe, Argentina.
2 UNL, FBCB (School of Biochemistry and Biological Sciences), CBL (Biotechnological Center of Litoral), Ciudad Universitaria, Ruta Nacional 168 Km 472.4, C.C. 242. (S3000ZAA), Santa Fe, Argentina.
3 Cellargen Biotech S.R.L., Antonia Godoy 6369, CP 3000, Santa Fe, Argentina.
4 Regulatory Biology Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037.
a These authors should be considered joint first author.
b Present address: Instituto de Agrobiotecnología del Litoral (CONICET-UNL), Cátedra de Biología Celular y Molecular, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, 3000 Santa Fe, Argentina.