Subjects
Healthy volunteers that meet the inclusion criteria and not the exclusion criteria were enrolled in the study after the clinical and laboratory examinations. The inclusion criteria included as follows:1)healthy male and female aged over 18years;2)the Body Mass Index is in the range of19.0 to 26.0 kg/m2 (both inclusive), and males with minimum of 50 kg weight, females with minimum of 45kg weight; 3)subjects have no clinically significant abnormalities, including vital signs, physical examinations, laboratory tests, and ECG as determined by clinical examination; 4)agree to follow approved birth control methods.
Subjects were excluded if any of the following conditions were present: 1)allergic diathesis or hypersensitivity toinvestigational products; 2)history or presence of significant cardiovascular, urogenital, pulmonary, hepatic, renal, gastrointestinal, endocrine, immunological, dermatological, neurological or psychiatric disease or disorder, or other medical history affecting drug absorption; 3)use of any drugs or herbal medicinewithin 14 days; 4)smoking more than five cigarettes a day, abuse of alcohol or drugs, drinking too much tea, coffee or caffeinated drinks (more than 8 cups a day, 250ml/cup); 5)donation or loss of blood or plasma >400mL in the past 3 months; 6)consumption of any beverages or food containing caffeine or products rich in grapefruit, such as coffee, tea and chocolate, etc,within 48 hours prior toreceiving study drug.