Figure 1. Experimental procedures and flow diagram of the
study.
(A ) Experimental procedures, drug delivery, and measurements
during baseline, cardiac arrest and cardiopulmonary resuscitation and
return of spontaneous circulation. (B ) Flow diagram of the
experiment. The whole study consisted of 2 parts. CA/CPR: cardiac arrest
and cardiopulmonary resuscitation; ECG: electrocardiogram; FFA:
flufenamic acid; FJC: Fluoro-Jade C; HR: heart rate; i.p.:
intraperitoneal injection; KO: Trpm4−/− mice;
PI: propidium iodide; ROSC: resuscitation and return of spontaneous
circulation; TUNEL: terminal deoxynucleotide transferase–mediated
dUTP-biotin nick-end labeling; WT: wild-type mice.