Key Results
In WT mice subjected to CA/CPR, FFA was effective in improving survival and neurologic outcome, reducing neuropathological injuries, attenuating brain edema, lessening leakage of IgG, restoring tight junction protein expression as well as promoting microglia/macrophages from the pro-inflammatory subtype towards the anti-inflammatory one. In comparison to WT mice, Trpm4−/− mice exhibited less neurologic deficiency, lighter histological impairment, more integrity of BBB and more anti-inflammatory microglia/macrophages polarization. As expected, FFA did not provide a benefit of superposition compared with vehicle in theTrpm4−/− mice after CA/CPR.