Conclusion and Implications
FFA mitigates BBB breach and modifies the functional status of microglia/macrophages, thereby improving survival and neurological deficits following CA/CPR. The neuroprotective effects are at least partially through interfering with the TRPM4 channel. These results provide significant clinical potentials to improve the prognosis for CA victims with successful resuscitation.
Keywords: Cardiac arrest, Flufenamic acid, Blood-brain barrier, Microglia/macrophages, Transient receptor potential M4