Key Results
In WT mice subjected to CA/CPR, FFA was effective in improving survival
and neurologic outcome, reducing
neuropathological
injuries, attenuating brain edema, lessening leakage of IgG, restoring
tight junction protein expression as well as promoting
microglia/macrophages from the pro-inflammatory subtype towards the
anti-inflammatory
one. In comparison to WT mice, Trpm4−/− mice
exhibited less neurologic deficiency, lighter histological impairment,
more integrity of BBB and more anti-inflammatory microglia/macrophages
polarization. As expected, FFA did not provide a benefit of
superposition compared with vehicle in theTrpm4−/− mice after CA/CPR.