Figure 1. Experimental procedures and flow diagram of the study.
(A ) Experimental procedures, drug delivery, and measurements during baseline, cardiac arrest and cardiopulmonary resuscitation and return of spontaneous circulation. (B ) Flow diagram of the experiment. The whole study consisted of 2 parts. CA/CPR: cardiac arrest and cardiopulmonary resuscitation; ECG: electrocardiogram; FFA: flufenamic acid; FJC: Fluoro-Jade C; HR: heart rate; i.p.: intraperitoneal injection; KO: Trpm4−/− mice; PI: propidium iodide; ROSC: resuscitation and return of spontaneous circulation; TUNEL: terminal deoxynucleotide transferase–mediated dUTP-biotin nick-end labeling; WT: wild-type mice.