Conclusion and Implications
FFA mitigates BBB breach and modifies the functional status of
microglia/macrophages, thereby improving survival and neurological
deficits following CA/CPR. The neuroprotective effects are at least
partially through interfering with the TRPM4 channel. These results
provide significant clinical potentials to improve the prognosis for CA
victims with successful resuscitation.
Keywords: Cardiac arrest, Flufenamic acid, Blood-brain barrier,
Microglia/macrophages, Transient receptor potential
M4