3.4 FFA prevented brain edema following CA/CPR
Considering brain edema is a key modulator of outcome after brain injury
from CA/CPR, we thus wondered whether FFA treatment has any influence on
CA-evoked brain edema. Cranial MRI was employed to visualize cerebral
edema at 72 h following CA/CPR. As shown, brain edema was prominent in
the vehicle-treated mice, whereas visibly prevented by FFA treatment
(Fig. 5A). The degree of abnormal water diffusion was quantified by
calculating the ADC values in regions of interest, including the cortex,
straitum, as well as hippocampus (Fig. 5B). FFA alleviated the reduction
of ADC values in each region of interest (Fig. 5C). The above data
illustrated that alleviation of cerebral edema could be attributed to
FFA-afforded
neuroprotection against CA/CPR.