3.4 FFA prevented brain edema following CA/CPR
Considering brain edema is a key modulator of outcome after brain injury from CA/CPR, we thus wondered whether FFA treatment has any influence on CA-evoked brain edema. Cranial MRI was employed to visualize cerebral edema at 72 h following CA/CPR. As shown, brain edema was prominent in the vehicle-treated mice, whereas visibly prevented by FFA treatment (Fig. 5A). The degree of abnormal water diffusion was quantified by calculating the ADC values in regions of interest, including the cortex, straitum, as well as hippocampus (Fig. 5B). FFA alleviated the reduction of ADC values in each region of interest (Fig. 5C). The above data illustrated that alleviation of cerebral edema could be attributed to FFA-afforded neuroprotection against CA/CPR.