Cell source
Application form
Route
Dosage
Modeling
Start time and end time
Outcome
Reference
Mice UC
Cell suspension
IV
5x105 Cells in 50 µL PBS
4 weeks hypoxia and 2 weeks hypoxia/SU5416
Treat at week 6, sacrifice at week 8
Treatment improves hemodynamic variables and histopathological alterations of PAH models
(Alencar et al., 2018)
Rat BM
Cell suspension
IV
1×106 cells in 1 ml PBS
3 weeks hypoxia /SU5416
Treat at week 1, Sacrifice at week 5
Treatment improves hemodynamic variables and histopathological alterations of PAH models
(J. Huang et al., 2020)
Mice BM
Exosome
IV
0.1µg or 10µg Exo in PBS once a day
3 weeks hypoxia
Treat at day 4, Sacrifice After week 4 hypoxia
Treatment improves hemodynamic variables and histopathological alterations of PAH models
(Lee et al., 2012)
Rat BM Microvesicle / Cell suspension
IV
MSCs once a day MSC-MVs once two days
One injection of MCT(50 mg/kg) for 3 weeks
Treat at week 4, Sacrifice at week 6.
Treatment improves hemodynamic variables and histopathological alterations of PAH models
(J. Y. Chen et al., 2014)
Rat AD
Cell suspension
IV
105 cells in 50 µl saline
One injection of MCT (60 mg/kg) for 2 weeks
Treat at week 2, Sacrifice at week 4
Treatment improves hemodynamic variables and histopathological alterations of PAH models
(de Mendonça et al., 2017)
Rat BM
Cell suspension
IV
3 × 106 cells in PBS
One injection of MCT (50 mg/kg) for 3 weeks
Treat at week 4, Sacrifice at week 6
Treatment improves hemodynamic variables and histopathological alterations of PAH models .
(Cheng et al., 2017)
Rat BM
Cell suspension
IT
3 × 106 cells in PBS
One injection of MCT (60mg/kg) for 2 weeks
Treat at week 3, Sacrifice at week 7
Treatment improves hemodynamic variables and histopathological alterations of PAH models
(Baber et al., 2007)
Rat BM
Cell suspension
IV
1 × 105 cells in 0.1 mL LR
Hyperoxia for 15 days
Treat at day 5, Sacrifice at day 15
Treatment improves hemodynamic variables and histopathological alterations of PAH models
(Suzuki et al., 2020)