3.31 Preclinical treatment with IPSCs in PAH
As an rising technology, rely on IPSCs to treat diseases has been applied in many fields including cardiovascular disease, neurodegenerative disease, it also includes respiratory diseases. Huang et al. use IPSCs and IPSCs-CM to treat MCT-induced PAH, the results show that IPSC-based therapy led to decreased accumulation of inflammatory cells and down-regulated the expression of pro-inflammatory factors through inhibit the phosphorylation of NF-κB pathway(W. C. Huang et al., 2016).