Cell
source
|
Application form
|
Route
|
Dosage
|
Modeling
|
Start time and end time
|
Outcome
|
Reference
|
Mice
UC
|
Cell suspension
|
IV
|
5x105 Cells in 50 µL PBS
|
4 weeks hypoxia and 2 weeks hypoxia/SU5416
|
Treat at week 6, sacrifice at week 8
|
Treatment improves hemodynamic variables and histopathological
alterations of PAH models
|
(Alencar et al., 2018)
|
Rat
BM
|
Cell suspension
|
IV
|
1×106 cells in 1 ml PBS
|
3 weeks hypoxia /SU5416
|
Treat at week 1, Sacrifice at week 5
|
Treatment improves hemodynamic variables and histopathological
alterations of PAH models
|
(J. Huang et al., 2020)
|
Mice
BM
|
Exosome
|
IV
|
0.1µg or 10µg Exo in PBS once a day
|
3 weeks hypoxia
|
Treat at day 4, Sacrifice After week 4 hypoxia
|
Treatment improves hemodynamic variables and histopathological
alterations of PAH models
|
(Lee et al., 2012)
|
Rat
BM
|
Microvesicle /
Cell suspension
|
IV
|
MSCs once a day
MSC-MVs once two days
|
One injection of MCT(50 mg/kg) for 3 weeks
|
Treat at week 4, Sacrifice at week 6.
|
Treatment improves hemodynamic variables and histopathological
alterations of PAH models
|
(J. Y. Chen et al., 2014)
|
Rat
AD
|
Cell suspension
|
IV
|
105 cells in 50 µl saline
|
One injection of MCT (60 mg/kg) for 2 weeks
|
Treat at week 2, Sacrifice at week 4
|
Treatment improves hemodynamic variables and histopathological
alterations of PAH models
|
(de Mendonça et al., 2017)
|
Rat
BM
|
Cell suspension
|
IV
|
3 × 106 cells in PBS
|
One injection of MCT (50 mg/kg) for 3 weeks
|
Treat at week 4, Sacrifice at week 6
|
Treatment improves hemodynamic variables and histopathological
alterations of PAH models .
|
(Cheng et al., 2017)
|
Rat
BM
|
Cell suspension
|
IT
|
3 × 106 cells in PBS
|
One injection of MCT (60mg/kg) for 2 weeks
|
Treat at week 3, Sacrifice at week 7
|
Treatment improves hemodynamic variables and histopathological
alterations of PAH models
|
(Baber et al., 2007)
|
Rat
BM
|
Cell suspension
|
IV
|
1 × 105 cells in 0.1 mL LR
|
Hyperoxia for 15 days
|
Treat at day 5, Sacrifice at day 15
|
Treatment improves hemodynamic variables and histopathological
alterations of PAH models
|
(Suzuki et al., 2020)
|