3.31 Preclinical treatment with IPSCs in PAH
As an rising technology, rely on IPSCs to treat diseases has been
applied in many fields including cardiovascular disease,
neurodegenerative disease, it also includes respiratory diseases. Huang
et al. use IPSCs and IPSCs-CM to treat MCT-induced PAH, the results show
that IPSC-based therapy led to decreased accumulation of inflammatory
cells and down-regulated the expression of pro-inflammatory factors
through inhibit the phosphorylation of NF-κB pathway(W. C. Huang et al.,
2016).