Recurrence and its related factors
Totally 5 patients recurred during follow-up period, and the recurrence rate was 1.33% in patients treated by hysterectomy and 0.65% in patients treated by cervical conization(s) alone, with no significant difference (p=0.431). In patients treated by hysterectomy, 3 recurred as VAIN1 and 1 recurred as VAIN3. While in patients treated by conization(s) alone, only 1 recurred as CIN1. VAIN patients were treated by electrocautery or vaginal diseases excision and CIN patient was treated by repeated conization.
Univariate and multivariate analysis were performed to evaluate the factors influencing recurrence in AIS patients. Univariate analysis showed that post-operative cytology and hrHPV-DNA status (both p=0.000) were significantly associated with recurrence (Table 3). Further, multivariate analysis revealed that post-operative cytology (OR=10.784, 95% CI 1.333-87.246) and HPV status (OR=23.413, 95% CI 2.097-261.453) were independent factors influencing recurrence. Both univariate and multivariate analysis did not demonstrate that surgery method was associated with recurrence.