Recurrence and its related factors
Totally
5 patients recurred during follow-up period, and the
recurrence
rate was 1.33% in patients treated by hysterectomy and 0.65% in
patients treated by cervical conization(s) alone, with no significant
difference (p=0.431). In patients treated by hysterectomy, 3 recurred as
VAIN1 and 1 recurred as VAIN3. While in patients treated by
conization(s) alone, only 1 recurred as
CIN1.
VAIN patients were treated by
electrocautery
or
vaginal diseases excision and CIN patient was treated by repeated
conization.
Univariate
and multivariate analysis were performed
to
evaluate the factors
influencing
recurrence in AIS patients. Univariate analysis showed that
post-operative cytology and hrHPV-DNA status (both p=0.000) were
significantly associated with
recurrence
(Table 3). Further, multivariate analysis revealed that post-operative
cytology (OR=10.784, 95% CI 1.333-87.246) and HPV status (OR=23.413,
95% CI 2.097-261.453) were independent factors influencing recurrence.
Both univariate and multivariate analysis did not demonstrate that
surgery method was associated with recurrence.