Results
Of the 92 patients randomized, 90 were included in the analysis and 2 patients dropped out of the trial because of the synergistic effect of others drugs. The study was conducted on two groups: the IIV group (n = 50) and the CIV group (n = 40) and various parameters were compared. The plateau concentration in the CIV group was higher than the trough concentration in the IIV group (15.22 mg.L-1 vs. 6.25 mg.L-1, P < 0.05). The AUC0–24/MIC of the IIV group was lower (median 391.45, interquartile ranges [IQR] 251.45–898.16) compared to that of the CIV group (429.60, [IQR] 220.92–769.20; P > 0.05). None of the two groups showed any significant difference in the clinical prognosis or the drug-induced nephrotoxicity.