Objectives
This study aimed: (a) to compare the effects of continuous (CIV) and
intermittent infusions of vancomycin (IIV) on the
pharmacodynamics/pharmacokinetics (PK/PD) at a dose of 40
mg.kg-1.d-1 in children with a
severe infection of gram-positive bacteria in the pediatric intensive
care unit; (b) to compare the outcomes and the frequency of the
drug-related adverse effects on renal function in this population.