Objectives
This study aimed: (a) to compare the effects of continuous (CIV) and intermittent infusions of vancomycin (IIV) on the pharmacodynamics/pharmacokinetics (PK/PD) at a dose of 40 mg.kg-1.d-1 in children with a severe infection of gram-positive bacteria in the pediatric intensive care unit; (b) to compare the outcomes and the frequency of the drug-related adverse effects on renal function in this population.