7. Concluding remarks
Melatonin serves as a potential anti-inflammatory agent through
regulation of mitophagy in macrophages in atherosclerotic regions. Thus,
melatonin along with other mitophagy regulators and inducers can form a
multiplex therapeutic package that can be delivered to macrophages to
confer desired effects on the amelioration of atherosclerosis.
Nanomedicine and drug delivery systems can be applied to guarantee the
specificity of this delivery and avoid off-target effects of the
therapeutic package.