7. Concluding remarks
Melatonin serves as a potential anti-inflammatory agent through regulation of mitophagy in macrophages in atherosclerotic regions. Thus, melatonin along with other mitophagy regulators and inducers can form a multiplex therapeutic package that can be delivered to macrophages to confer desired effects on the amelioration of atherosclerosis. Nanomedicine and drug delivery systems can be applied to guarantee the specificity of this delivery and avoid off-target effects of the therapeutic package.