MA-5 |
Mitochonic acid 5 |
PRKN-dependent mitophagy via activation of
AMPK-SIRT3, improves mitochondrial function, suppresses oxidative
stress, attenuates TNF (tumor necrosis factor)-induced inflammation |
(Huang, Liu & Jiang, 2019) |
Puerarin |
Derived from Pueraria with antioxidant capacity |
Regulates
mitochondrial fission and fusion, reactivates PINK1-PRKN-mediated
mitophagy, alleviates inflammation by interfering with TLR4 (toll like
receptor 4)-NFKB1 axis |
(Chen et al., 2018) |
TMP |
2,3,5,6-Tetramethylpyrazine |
Blocks CCL2 (C-C motif chemokine
ligand 2)-CCR2 (C-C motif chemokine receptor 2)-mediated inflammation,
maintains mitochondrial dynamics, alleviates oxidative stress, and
activates mitophagy |
(Gong, Duan, Zheng, Ye & Hei,
2019) |
Tributyrin |
A natural triglyceride that exists in butter |
Enhances
PRKN, ameliorates mitochondrial dysfunction and boosts membrane
potential, eliminating oxidative stress |
(Wang et al.,
2019) |
Undecanone |
2-Methyl nonyl ketone derived from H. cordata
|
Mitophagy activation via inhibition of AKT1-MTORC1, and inhibits
inflammation in vivo and in vitro
|
(Wu et al.,
2021) |