AUTHOR CONTRIBUTIONS
BP and LS conducted most of the experiments, completed the data and
contributed equally to this work. Meng Zhang offered assistance in
animal model preparation and experimental operation details; Huacheng
Yan was involved in patient related experiments including specimen
acquisition, handling and analysis; Guochao Shi made substantial
contributions to the design and conduct of the experiment. Zhenwei Xia
provided the indispensable experimental platform and constructive
guidance. WT and Ranran Dai conceived the project and led the study
design, supervised the study, reviewed the manuscript and provided final
confirmation of the revised version to be published. All authors have
read and approved the final version of manuscript.