Figure 4. IL-25 deficiency ameliorates HDM-Induced airway inflammation.
(A) Schematic representation of house dust mite (HDM)-induced allergic airway inflammation of wild-type and global IL-25-/-mice.
(B) Serum IgE level after HDM or PBS challenge.
(C) HE&PAS lung histology images of wild-type and global IL-25-/- mice during PBS or HDM challenge. Scale bars: 50 μm
(D) Absolute cellularity of total cells in BALF of mice in (A).
(E) Flow plots showing the percentage (left) and qualification (right) of BALF eosinophils (CD45+SiglecF+CD11c-) infiltration into airways after HDM or PBS challenge.
(F-H) BALF IL-4(F), IL-5(G), IL-13(H) cytokine concentration, respectively, in wild-type and global IL-25-/- of HDM challenged mice.
n= 4~5, ANOVA (C, D, E, F, G and H) , *p<0.05 **p<0.01 ****p<0.0001