AUTHOR CONTRIBUTIONS
BP and LS conducted most of the experiments, completed the data and contributed equally to this work. Meng Zhang offered assistance in animal model preparation and experimental operation details; Huacheng Yan was involved in patient related experiments including specimen acquisition, handling and analysis; Guochao Shi made substantial contributions to the design and conduct of the experiment. Zhenwei Xia provided the indispensable experimental platform and constructive guidance. WT and Ranran Dai conceived the project and led the study design, supervised the study, reviewed the manuscript and provided final confirmation of the revised version to be published. All authors have read and approved the final version of manuscript.