Research end point Research number Heterogeneity test Heterogeneity test Outcome Outcome Outcome
Low-risk group P value I2(%) RR 95%CI P value
30-days
All-cause mortality 3 0.92 I2=0 0.44 [0.20, 0.98] 0.04
Cardiovascular mortality 3 0.95 I2=0 0.47 [0.21, 1.03] 0.06
Stroke 3 0.11 I2=54 0.57 [0.22, 1.48] 0.25
Transient ischemic attack 3 0.25 I2=27 0.75 [0.17, 3.37] 0.71
Myocardial infarction 3 0.81 I2=0 0.65 [0.34, 1.22] 0.18
Acute kidney injury ( stage 2 or 3)
3
0.54
I2=0
0.27
[0.14, 0.56]
0.0003
Life-threatening or disabling bleeding 3 0.002 I2=83 0.29 [0.14, 0.61] 0.001
Permanent pacemaker implantation 3 0.002 I2=84 3.59 [1.43, 9.03] 0.006
New-atrial fibrillation 3 0.03 I2=72 0.21 [0.14, 0.31] <0.00001
1-year
All-cause mortality 3 0.52 I2=0 0.69 [0.43, 1.10] 0.12
Cardiovascular mortality 3 0.83 I2=0 0.56 [0.33, 0.94] 0.03
Stroke 3 0.24 I2=0 0.71 [0.40, 1.25] 0.23
Transient ischemic attack 3 0.91 I2=0 0.98 [0.52, 1.83] 0.94
Myocardial infarction 3 0.57 I2=0 0.74 [0.43, 1.27] 0.28
Life-threatening or disabling bleeding 2 0.53 I2=0 0.32 [0.24, 0.42] <0.00001
Permanent pacemaker implantation 3 0.0002 I2=88 3.42 [1.33, 8.82] 0.01
New-atrial fibrillation 3 0.03 I2=69 0.25 [0.18, 0.36] <0.00001
2-years
All-cause mortality 2 0.99 I2=0 0.79 [0.46, 1.35] 0.38
Cardiovascular mortality 2 0.83 I2=0 0.66 [0.36, 1.20] 0.17
Stroke 2 0.96 I2=0 0.68 [0.37, 1.26] 0.22
Transient ischemic attack 2 0.21 I2=36 1.09 [0.39, 3.04] 0.87
Myocardial infarction 2 0.99 I2=0 0.79 [0.46, 1.35] 0.38
Permanent pacemaker implantation 2 <0.0001 I2=94 3.58 [0.45, 28.74] 0.23
New-atrial fibrillation 2 0.009 I2=85 0.27 [0.14, 0.51] <0.0001