Demographics and Clinical Characteristics of Patients at
Baseline
From January 2009 to December 2020, a total of 75 patients with
definitive PCD diagnoses were admitted to the Department of Respiratory
Medicine, Beijing Children’s Hospital. Clinical and genetic
characteristics of patients were collected and analyzed during the
follow-up period. Of the total of 75 PCD patients, 63 patients received
follow-up care, 7 patients were lost to follow-up, 4 refused to
participate, and 1 patient died of severe complex congenital heart
disease at 1 year of age. In summary, follow-up data were obtained from
a total of 63 patients, of which 35 patients were males and 28 were
females; the overall median duration of the follow-up period after
diagnosis was 3.1 years (ranging from four months to 9.4 years) and the
average age at diagnosis was 7.6 ± 3.3 years.
Age, sex and clinical characteristics between AZM-treated and
AZM-untreated groups of PCD patients were very similar at baseline
(Table 1, partly reported in previous studies[12]) except for FEF25-75%
predicted values, which were lower in the
AZM-treated group than in the
AZM-untreated group (46.9 ± 20.8 VS 70.8 ± 28.0, P =
0.008, respectively).