1.4.2 Dose modifications
The cetuximab dose was reduced if a patient experienced an uncontrollable and persistent grade 2 acne-like rash. Chemotherapy doses and regimens were adjusted based on the severity of myelosuppression, hepatic and renal function and drug sensitivity. For example, carboplatin was administered instead of cisplatin if grade 1 renal toxicity was caused by cisplatin.