1.4.2 Dose modifications
The cetuximab dose was reduced if a patient experienced an
uncontrollable and persistent grade 2 acne-like rash. Chemotherapy doses
and regimens were adjusted based on the severity of myelosuppression,
hepatic and renal function and drug sensitivity. For example,
carboplatin was administered instead of cisplatin if grade 1 renal
toxicity was caused by cisplatin.