Evaluating the efficacy of compound MP-010 in preserving MN loss in SOD1G93A mice
At the end of functional follow-up, spinal cord was harvested for histological studies. The quantification of alpha MNs in the ventral horn of spinal cord sections stained with cresyl violet revealed that untreated control SOD1G93A mice experienced a loss of over 60% of MNs compared to WT mice at 16 weeks of age (Fig. 3C,D). The administration of MP-010 at 61mg/kg significantly increased the number of surviving MNs in SOD1G93A mice, whereas the dose of 122 mg/kg MP-010 did not mitigate MN loss (Fig. 3C,D).