Figure 5. Marginal extension of survival and attenuation of weight loss in SOD1G93A mice upon MP-001 administration.
A) Schematic diagram of the experimental design for the trial to test MP-001.
B) Mice treated with MP-001 exhibited reduced weight loss at 13-15 weeks of age.
C) Treated mice displayed a slightly longer lifespan compared to untreated counterparts, but the differences were not statistically significant, as determined by the Log-rank (Mantel-Cox) Test.
D) The treated and control animals demonstrated comparable results concerning motor coordination in the rotarod test.
E) SOD1G93A mice under treatment did not exhibit an improvement in motor strength, as assessed in the hanging-wire test.
Mean ± SEM are represented in the plots. Two-way ANOVA with Bonferroni’s multiple comparisons test was employed. *p < 0.05 compared to the SOD1G93A vehicle group.