Figure 2. Improvement of Motor Function in
SOD1G93A Mice upon MP-010 Treatment.
A) Schematic diagram of the experimental design for the trial
whose data are shown in this figure and figure 3.
B) Plot of the percentage of body weight for the different mice
groups during the follow-up period. Body weight results are expressed as
a percentage relative to baseline values for each mouse.
C-D) Electrophysiological tests illustrating the preservation
of compound muscle action potentials (CMAP) amplitude in the tibialis
anterior (TA) muscle but not in the plantar interosseous (PL) muscle at
16 weeks of age. Amplitude values of CMAP are presented as a percentage
relative to the baseline value for each mouse.
E) Graph depicting the impact of different MP-010 treatments on
functional outcome in the rotarod test.
Mean ± SEM are represented in the plots. Two-way ANOVA with Bonferroni’s
multiple comparisons test was employed. *p < 0.05 compared to
the SOD1G93A vehicle group. Each colored * represents
the comparison between each group (defined by colors on panel A) and the
SODG93A vehicle group (grey).