Figure 4. Enhanced Survival and Amelioration of Motor Symptoms
in SOD1G93A Mice Treated with MP-010.
A) Schematic diagram of the experimental design of this trial.
B) Plot illustrating the percentage of body weight for
different mouse groups during the follow-up period. Body weight results
are expressed as a percentage relative to baseline values for each
mouse.
C) Survival curves indicate that treated mice exhibited a
longer lifespan compared to untreated counterparts, as determined by the
Log-rank (Mantel-Cox) test. *p = 0.017 compared to the
SOD1G93A vehicle group.
D) MP-010 treatment resulted in an improvement in motor
coordination, as assessed by the rotarod test.
E) MP-010 treatment did not lead to improved motor strength, as
evaluated in the hanging-wire test.
Mean ± SEM are represented in the plots. Two-way ANOVA with Bonferroni’s
multiple comparisons test was employed. *p < 0.05 compared to
the SOD1G93A vehicle group.