Evaluating the efficacy of compound MP-010 in preserving
MN loss in SOD1G93A mice
At the end of functional follow-up, spinal cord was harvested for
histological studies. The quantification of alpha MNs in the ventral
horn of spinal cord sections stained with cresyl violet revealed that
untreated control SOD1G93A mice experienced a loss of
over 60% of MNs compared to WT mice at 16 weeks of age (Fig. 3C,D). The
administration of MP-010 at 61mg/kg significantly increased the number
of surviving MNs in SOD1G93A mice, whereas the dose of
122 mg/kg MP-010 did not mitigate MN loss (Fig. 3C,D).