Figure 5. Marginal extension of survival and attenuation of
weight loss in SOD1G93A mice upon MP-001
administration.
A) Schematic diagram of the experimental design for the trial
to test MP-001.
B) Mice treated with MP-001 exhibited reduced weight loss at
13-15 weeks of age.
C) Treated mice displayed a slightly longer lifespan compared
to untreated counterparts, but the differences were not statistically
significant, as determined by the Log-rank (Mantel-Cox) Test.
D) The treated and control animals demonstrated comparable
results concerning motor coordination in the rotarod test.
E) SOD1G93A mice under treatment did not
exhibit an improvement in motor strength, as assessed in the
hanging-wire test.
Mean ± SEM are represented in the plots. Two-way ANOVA with Bonferroni’s
multiple comparisons test was employed. *p < 0.05 compared to
the SOD1G93A vehicle group.