Results
Baseline clinical characteristics
Finally, 64 patients with ESRD were enrolled, including 37 males and 27 females, aged 25-79 (49.6 ± 14.9) years, height 167.8 ± 7.4 cm, pre-dialysis weight 61.0 ± 10.3 kg, body surface area (BSA) 1.69 ± 0.16 m2, median dialysis age 24.0 (7.5, 59.5) months, fluid removal 2.0 ± 0.84 L. There were 30 healthy controls in the same period, including 17 males and 13 females, aged 24-74 (47.7 ± 16.6) years, height 164.1 ± 7.2 cm, body weight 61.2 ± 9.2 kg, BSA 1.67 ± 0.14 m2 , as shown in Table 1.
Difference of Conventional echocardiographic measurements
Compared with the control group, SBP, DBP, LVEDV, LVESV, SV, RA, RV, CO, LAV, LAVI, E-peak, A-peak, E/E ’and PASP in ESRD group were higher than those in the control group (P < 0.05), while septal e’ and lateral e’ in ESRD group were lower than those in the control group (P < 0.05). There was no significant difference in LVEF, heart rate, E/A, EDT between the two groups (P> 0.05).
Compared with before hemodialysis, SBP, LVEDV, LVESV, SV, RA, RV, CO, LAV, LAVI, E peak, A peak, E/A, septum E ’, sidewall E’ and PASP after hemodialysis were significantly lower than those before hemodialysis (P < 0.05); There was no significant difference in DBP, LVEF, heart rate, EDT and E/E’between the two groups (P> 0.05), as shown in Table 2.
Difference of strain parameters
Compared with the control group, there was no significant difference in LVGLS parameters (subendocardium, midmyocardium and subepicardium) before hemodialysis (P> 0.05). Before hemodialysis, the left atrial strain parameters (LASr, LAScd, LASct) were significantly lower than those of the control group (P < 0.05).
Compared with before hemodialysis, LVGLS (subendocardium, midmyocardium and subepicardium) decreased after hemodialysis, and the difference was statistically significant (P < 0.05). After hemodialysis, LASr and LAScd decreased, and the difference was statistically significant (P < 0.001). There was no significant difference between LASCT and before hemodialysis (p> 0.05), as shown in Table 3.