Fig.6: GSVA showed significant correlation between inflammatory neutrophils and measures of disease severity.
RNAseq data from MHV-1 and mock-infected lean and obese C3H/HeJ mice was analyzed by GSVA using immune cell (A) and inflammatory and cellular pathway (B) gene signatures.
Linear regression analysis between inflammatory neutrophil GSVA scores and weight loss (C), lung histopathology (D) and liver histopathology (E). Linear regression analysis between activated B cell GSVA scores and weight loss (F), lung histopathology (G) and liver histopathology (H). The correlation for each comparison is displayed as the r2 value and the significance of the correlation is displayed as the p-value. Statistical and regression analysis was done using GraphPad Prism. The level of significance is represented as follows: p < 0.05 (*); p < 0.001 (**); p = 0.001 to 0.0001 (***); p < 0.0001 (****). The error bars indicate SD of the mean.