Study population
We included finalized multicentre RCTs supported by the clinical trial
centre and performed within the Dutch Consortium for Women’s Health
Research, between March 1st 2003 and December
1st 2023. We excluded studies with an observational
design, single centre RCTs, RCTs initiated outside the Netherlands, RCTs
with a cluster or parallel study design, RCTs that never actually
started, RCTs in which inclusion of patients was still ongoing and RCTs
prematurely discontinued for other reasons than poor recruitment, for
example due to safety issues after an interim analysis.