Cross-reactive antibody responses to coronaviruses elicited by SARS-CoV-2 infection or vaccination
Richard SH Lee1, Samuel MS Cheng1, Jin Zhao1, Annie YS Tsoi1, Kaman KM Lau1, CoCo HC Chan1, John KC Li1, David SC Hui2, Malik Peiris1,3*, Hui-Ling Yen1*
1School of Public Health, LKS Faculty of Medicine, The University of Hong Kong
2Department of Medicine and Therapeutics, CUHK, Prince of Wales Hospital, HKSAR, China
3Centre for Immunology & Infection, Hong Kong Science Park, Hong Kong, China
Running title: SARS-CoV-2 and cross-reactive antibodies
Key words: SARS-CoV-2, human coronaviruses, cross-reactive antibody, COVID-19 vaccines, convalescent sera
Word count: 214 words (abstract), 2211 words (text); Figures: 3; References: 22.
Notes:
  1. The authors declare no conflict of interest.
  2. Data is available upon request from the corresponding author.
  3. This study was supported by the HKU URC Seed Funding for Strategic Interdisciplinary Research Scheme 2021/22, Contract (U01AI151810) of NIAID, National Institutes of Health, USA, and the Theme-based Research Scheme (#T11-705/21-N) of the Research Grants Council of the Hong Kong SAR Government, China.
  4. The study was approved by the institutional review board of the Hong Kong West Cluster of the Hospital Authority of Hong Kong (Reference No.: UW20-169) and the Joint Chinese University of Hong Kong-New Territories East Cluster Clinical Research Ethics Committee (Reference No.: 2020.229).
  5. Correspondence: Hui-Ling Yen (hyen@hku.hk) and Malik Peiris (malik@hku.hk).