Statistical Analysis:
Data was analysed using IBM SPSS version 25 Inc, Chicago, IL and RStudio software version 2023.03.0. Descriptive statistics were represented as median or percentages. T-tests or linear regression models were used to analyse continuous measures and chi-square tests, tests of proportions and logistic regressions were used to analyse binary data. Survival was estimated using Kaplan-Meier method and compared using a log-rank test. The primary outcome was event-free survival (EFS). Secondary outcomes were overall survival (OS) and histological necrosis. Effect of covariates on survival were estimated using Cox proportional hazards analysis. Significant factors on univariate analysis were tested in multivariate analysis.