Statistical Analysis:
Data was analysed using IBM SPSS version 25 Inc, Chicago, IL and RStudio
software version 2023.03.0. Descriptive statistics were represented as
median or percentages. T-tests or linear regression models were used to
analyse continuous measures and chi-square tests, tests of proportions
and logistic regressions were used to analyse binary data. Survival was
estimated using Kaplan-Meier method and compared using a log-rank test.
The primary outcome was event-free survival (EFS). Secondary outcomes
were overall survival (OS) and histological necrosis. Effect of
covariates on survival were estimated using Cox proportional hazards
analysis. Significant factors on univariate analysis were tested in
multivariate analysis.