Case presentation:
A 41-year-old man with known sickle cell anaemia (Hb SS) who had a
history of frequent vaso-occlusive crises. In the year prior to starting
treatment with crizanlizumab, the patient had three pain crises at home
without visiting the emergency department, three pain crises for which
he was admitted to hospital, one crisis of acute chest syndrome and
recurrent episodes of stuttering priapism that occurred almost weekly,
each episode lasting approximately 3-5 minutes and having a pain score
of 5-6 and usually resolving spontaneously. During this time. he
continued to receive folic acid 5 mg daily, hydroxyurea 1000 mg daily
and an increasing requirement for narcotics, so the patient was offered
to increase the dose of hydroxyurea, which he refused.