2.4 Quality assessment
Quality assessment of RCTs was performed using the Cochrane Collaboration’s tool for assessing risk of bias in randomized trials (RoB-2), in which studies are scored as high, low, or unclear risk of bias in 5 domains: selection, performance, detection, attrition, and reporting biases. 12 Publication bias was investigated, for outcomes that included all studies in this meta-analysis, by funnel-plot analysis of point estimates according to study weights.