Figure 3 A: HDL levels were significantly higher in the FGF21 analog group. B: Pro C3 was significantly lower in the FGF21 analog group. IV: Inverse Variance; CI = Confidence Interval; M-H: Mantel Haenszel; SD = Standard Deviation.
In those who received the intervention, there was a statistically significant reduction in levels of PROC3 (MD -6.12; 95% CI -8.05 to -4.20; p=0.09; I²=46%; Figure 3B). Furthermore, there was no significant difference in NASH resolution between both groups (RR 3.57; 95% CI 0.91 to 13.94; p=0.07; I²=54%; Figure 4). On sensitivity analysis, we removed FALCON 1 due to the high risk of bias. After its removal, statistically significant results were found (RR 7.14; 95% CI 2.27 to 22.44; I²=0%; Figure S14).
3B: Pro C3 was significantly lower in the FGF21 analog group. IV: Inverse Variance; CI = Confidence Interval; M-H: Mantel Haenszel; SD = Standard Deviation.