Figure 6. The effects of vortioxetine (VOR) and duloxetine (DLX)
treatment on the mRNA expression of Il -1β, Tnf-α, Ngf, Bdnf andTac1 in the dorsal root ganglia (DRG) (A) and spinal cord (B) of
male rats with monoiodoacetate (MIA)-induced osteoarthritis. L3-L5
ipsilateral DRGs and spinal cord cross sections were isolated 28 days
after MIA/saline injection and mRNA expression of Il-1β, Tnf-α,
Ngf, Bdnf and Tac1 was determined by quantitative real-time PCR.
VOR/DLX was administered orally once daily for 28 days after MIA
injection. Statistical significance was determined in comparison with
the saline control group (#P < 0.05,##P < 0.01,###P < 0.01) or the MIA control
group (*P < 0.05, **P < 0.01,
***P < 0.001) using one-way ANOVA followed by Tukeypost-hoc test. Data are plotted as mean ± SEM.