Vortioxetine improved weight distribution and attenuated mechanical hypersensitivity in rats with MIA-injected knees
Intra-articular injection of MIA resulted in a significant reduction in weight placed on the injected limb and the development of mechanical allodynia of the ipsilateral hind paw (post-hoc P< 0.001 compared to saline controls; Figures 2 and 3, respectively). These changes persisted throughout the observation period (28 days). The maximum decrease in weight bearing and paw withdrawal thresholds was reached on day 4 post-injection and amounted to 41.19% in males and 33.67% in females (weight bearing), and 35.18% in males and 36.15% in females (von Frey), compared to sham controls. No sex differences in the magnitude of behavioural pain-related responses to MIA were observed over the entire observation period (AUC for weight-bearing post-hoc P = 0.380; AUC for mechanical allodynia post-hoc P = 0.180; Table 1). OA induction had no effect on rotarod performance (post-hoc P ≥ 0.273; Supplementary Figure 1).