Figure 2 . Treatment with vortioxetine (VOR)
and duloxetine (DLX) reduced weight-bearing deficits in male (A) and
female (B) rats with monoiodoacetate (MIA)-induced knee osteoarthritis.Results were presented as time course data of weight-bearing and area
under the curve (AUC) obtained during the 28 days of the experiment.
VOR/DLX was administered orally once daily for 28 days following MIA
injection (indicated by arrows). Statistical significance was determined
in comparison with the saline control group
(###P < 0.001) or the MIA control
group (*P < 0.05, **P < 0.01,
***P < 0.001) using a two-way ANOVA with repeated
measures (time course data) or one-way ANOVA (AUC data) followed by
Tukey post-hoc test. Data are plotted as mean ± SEM of
weight-bearing (%)/AUC values.