Results
A total of 24 rat, divided into 3 groups of 8 rat each, were observed throughout the duration of the experiment. Table 1 shows the baseline ECHO parameters of the three groups. There is no difference between the groups when comparing echo parameters at baseline. Table 2 shows the echo parameters of the control group on days 0, 15 and 30, table 3 shows the dapagliflozin and table 4 shows the sacubitril/valsartan group.
When comparing baseline data, there was no significant difference observed in the performance of rotarods and their corresponding weights. Table 5 shows the change in the rat’s weight over the course of the experiment, and Table 6 shows the results from the rotarod follow-ups.
Table 7 shows the median swimming times of each group during the swimming sessions throughout the experiment. Starting from the 9th swimming session, there was a noticeable difference in the swimming times between the groups. Figure 1 displays the average swimming performance of the three groups. Table 8 shows the comparison of sacubitril/valsartan with the control group, and table 9 shows the comparison of dapagliflozin with the control group.