Background
Wherein, the ultra-short-lived positron-emitting radionuclide fluorine-18 (half-life of 110 min) is the main nuclide for the majority of the radiotracers used in PET / CT.ω-[18F]fluoroaliphatic carboxylic esters and acids  are the promising precursors for PET.
Aims
The aim of the work was to choose ω-Iodoaliphatic carboxylic esters, which can be used to obtain prosthetic group, followed by the creation of various targeted radiotracer molecules for PET / CT.
Methods
ω-Iodoaliphatic carboxylic esters were described previously. The Synthra RN Plus synthesizer was used for the synthesis. The synthesis sequence was modified to allow the unit operations needed for the synthesis of esters(Figure 1). Radiochemical yields (RCY) and radiochemical purity (RCP) were assessed by analytical radio-TLC of the reaction mixture.
Results and Conclusion
RCP of the product was noted to be over 95%. The highest RCY was obtained during fluorinating of methyl 6-iodohexanoate. We selected methyl 6-iodohexanoate from the available ω-iodoaliphatic carboxylic esters and acids, which we will use in the future for the radio synthesis of the bifunctional prosthetic group.
References
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