Background
We have been conducting basic and clinical studies on the positron emission tomography tracer of glutamate neurotransmission systems. The 3Lots test of 11C-ABP688 tracer for mGluR5 has already been completed. Currently, we are researching the 18F introduction tracer.
Aims
Although 11C-ABP688 is a useful tracer; however, due to its half-life, it is limited to short-time measurement. On the contrary, some 18F tracers for several mGluR5 have been developed. In this study, we aimed at the in silico binding assay analysis of 11C-ABP688 and 18F tracers.
Methods
In the in silico binding assay, the stable structure of 11C-ABP688 binding with mGluR5 was calculated and the binding mode was analyzed. Also, the details of the mGluR5 binding activity of several 18F tracers were examined.
     
Results and Conclusion
Using Gaussian and AutoDock analytical tools, the in silico binding assay showed binding patterns similar to that of 11C-ABP688 in some 18F tracers (such as 18F-PSS232). Because some 18F tracers require two-step (one-pot) synthesis, we are currently investigating the sequencing production and labeling synthesis using the current equipment.
References
1. Simon M Ametamey et al., J Nucl Med,47(4), 698-705, 2006
2. Adrienne Müller Herde et al., J Neurochem, 133(3), 330-42, 2015
3. Geoffrey Warnock et al., Eur J Nucl Med Mol Imaging, 45(6), 1041-1051, 2018