L'essai clinique de phase III vient de se finir. Another strategy is to use PACA with PEG and by click chemistry graft biotine for consecutive addition of streptavidine antibody. Several issues for translating and drugs are burst release, total drug loading is only 5% in PACA.
Squalene strategy: Using ultra folded conformation, chemically drug addition on squalene , changing solvents allows self-assembly of 100nm particles. They obtained 60% loading of cisplastin and also efficient anticancer siRNA loading. SQ-NPs use LDL as indirect carrier to target high expressing LDL receptor of tumor cells.
Difference of structure observed for SQ-NPs between TEM and cryoTEM : Initially sphere, in cryoTEM they look more like rods.
Cardiotoxicity of DOX is also reduced when loaded in SQ-NPs compared to DOX alone, in hypertensive rat model assessed by troponine blood level. DOX half life is increased. Tumor growth is totally inhibited for hepatocarcinoma.
In coloadenocarcinoma model, SQ-NPs loaded with cisplatine, ROS production is increased.
SQ-NPs with adenosine use before and after ischemic episode : decrease infarct zone with SQ-Ads treatment. It goes through blood-brain barrier.
NanoMOFs allows no crystallization of an pediatric oncodrug Bersulfan with 30% loading. Diacids of the MOFs compete with phosphate of the body and neutral pH cause release of diacids which triggers aggregates.
Yannick Cremillieux - Institute of molecular sciences Bordeaux - Aerosol administration of theranostics nanoparticles: from imaging to therapy