SESSION 1 : Design and charaterization of nanomedicines 

Kazunori Kataoka - University of Tokyo Japan - Self assembled supramolecular nanosystems for smart diagnosis and targeted therapy of intractable diseases 

Mainly working on polymeric micelles 70nm / 30nm core-shell architecture. 70nm are stuck in the vicinity of the blood vessel and 30nm can go through = differential release. Last study on grafting glucose in polymeric micelles to target GLUT1 receptor and cross blood brain barrier for delivering versatile drugs in Alzheimer disease. 

Elias Fattal - IGPS Paris Sud - Long circulating nanoparticles of a lipophilic prodrug of dexamethasone for the treatment of rheumatoid arthritis

Glucocorticoids drugs has poor pharmacokinetics. Liposomes is not enough. Dexamethasone palmitate efficient loading can be achieved in this case by mixing with PEGylated phospholipids. Nanoparticles obtained were 130nm size, -45mV, 49% dexamethasone palmitate content. Biodistribution less in liver, slight increase in spleen, fluorescent NPs proved their specific accumulation into inflamed joints. Led to a significant improvement in arthritis mice model. 

Chun Yin Lau - Utrecht university Netherlands - Towards rational molecular engineering: a computational-experimental approach to tailor and characterize self assembling peptide nanostructures

Johanna Tran - IGPS Paris Sud - Radical copolymerization  of vinyl ethers and cyclic ketene acetals: a new platform to challenge traditional polyesters for biomedical applications 

Mix between cyclic ketene acetal (CKA) and monomers of vinyl ether derivatives. Copolymerization predicted by DFT calculation before confirmed. Then, functionalized by fluorescent probes (rhodamine) or PEG chains by click chemistry for a total 144nm size. Biofilms and tissue engineering applications.

Charlotte Boitard - PHENIX Jussieu with Christine ménager - Surface-initiated synthesis of bulk-imprinted magnetic polymer for protein recognition

Magnetic imprinted polymer nanoparticles. Prepolymerisation complex between proteins and acrylamide by bulk approach. Maghemite nanoparticles added for grafting of polymer matrix on surface \cite{Boitard2017} .

Damien Mertz - University of Strasbourg - Protein-based hybrid magnetic nanoplatforms for theranostic applications

Using isobutyramide (IBAM) they non-covalently complex proteins to form hollow particles. H-bonds between IBAM and polypeptidic chains. They used insulin and human serum albumin (HSA). Protease degradation or reductive cytosolic conditions allows drug release \cite{Mertz_2012,Mertz2014}.  Gadolinium and siRNA delivery with 100nm size nanoparticles. New systems use magnetic core and silica shell, doxorubicin loading and HSA coating, release measured in protease mimicking medium. The approach was translated with carbon nanotubes in core for release with NIR light. 

Nasser Mohamed Said - UMR6213 UTINAM Besançon - golden nanoflowers designed for image-guided radiotherapy.

Polyaminocarboxylate chelator for Gadolinium and gold. Rapid renal clearance, so they use maghemite nanoflowers as core and coat them with Au@L-Gd for a total 30nm size. They can associate Radiosensitizing effect with magnetic hyperthermia. 

Sponsor presentations 

Malvern instruments 
Izon 
Labex TRAIL 
Anton Paar 
Cordouan : français, et fabrication sur site. DLS combiné avec hyperthermie 
Wyatt 
Specific polymers