Thus, while feeding behaviors and their interactions with the state of the animal provide a technically accessible model to study decision-making and action selection, the interrelation between the consequences of starvation on motor control, motivation, stress and the metabolic state of the animal pose a formidable experimental challenge, in particular in the interpretation of the different phenotypes linked with biogenic amine disruption. Leveraging the neurogenetic tools in Drosophila, we attempted to understand how starvation influences the animal's decision-making with regard to feeding-related stimuli. Specifically, we investigated the involvement of the OA/TA-system on starvation-dependent modulation of sugar responsiveness and metabolism. We asked whether the OA/TA-system was involved in the physiological response to starvation or the neuronal changes following starvation, and whether its neuronal action was peripheral or central. Our results corroborate and extend the previous findings on the promiscuous effects of these biogenic amines and suggest that both OA and TA are involved in most of the counterregulatory processes, which occur in parallel.