Polysaccharide and Zn nanoparticles based elastomeric semi-IPN
nanocomposites for sustain and controlled drug delivery
AbstractHydrogel based soft materials have earned considerable interest as
promising systems for biomedical filed as a consequence of their
numerous properties likes softness, biodegradability, and
hydrophilicity. The polysaccharide and natural polysaccharide have the
numerous properties like nontoxicity, biodegradability, availability.
The polysaccharide gums have outstanding benefits such as renewable,
biodegradable, biocompatibility,and nontoxic. The uncontrolled release
of drug and sufficient strength of hydrogels are challenges for the
researcher to develop the advanced materials for the drug delivery
application. An addition of inorganic nanoparticles in the hydrogels
leads to improve matrix properties regarding robustness and sustain drug
release profile. The rheological profile of nanocomposites hydrogels
were established by carrying out amplitude sweep and frequency sweep.
The release profile of prepared nanocomposites hydrogels was studied by
utilizing ofloxacin as a model drug in different pH media, different
content of nanoparticles and different intervals.