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Cardiac Mechanics in Heart Failure with Preserved Ejection Fraction
  • Karthik Seetharam,
  • Partho Sengupta,
  • Christopher Bianco
Karthik Seetharam
Mount Sinai Hospital
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Partho Sengupta
West Virginia University School of Medicine
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Christopher Bianco
West Virginia University Heart and Vascular Institute
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Abstract

Heart failure with preserved ejection fraction (HFpEF) is a complex clinical entity associated with significant morbidity and mortality. Common comorbidities including hypertension, coronary artery disease, diabetes, chronic kidney disease, obesity, and increasing age predispose to preclinical diastolic dysfunction that often progresses to frank HFpEF. That said, clinical HFpEF is typically associated with some degree of diastolic dysfunction or can occur in the absence of many conventional diastolic dysfunction indices. The exact biologic links between risk factors, structural changes, and clinical manifestations are not clearly apparent. Innovative approaches including deformation imaging have enabled deeper understanding of HFpEF cardiac mechanics beyond conventional metrics. Furthermore, predictive analytics through data driven platforms have allowed for a deeper understanding of HFpEF phenotypes. This review focuses on the changes in cardiac mechanics that occur through preclinical myocardial dysfunction to clinically apparent HFpEF.

Peer review status:ACCEPTED

11 Apr 2020Submitted to Echocardiography
13 Apr 2020Submission Checks Completed
13 Apr 2020Assigned to Editor
13 Apr 2020Reviewer(s) Assigned
01 May 2020Review(s) Completed, Editorial Evaluation Pending
02 May 2020Editorial Decision: Revise Minor
22 May 20201st Revision Received
22 May 2020Submission Checks Completed
22 May 2020Assigned to Editor
22 May 2020Reviewer(s) Assigned
22 May 2020Review(s) Completed, Editorial Evaluation Pending
23 May 2020Editorial Decision: Accept