The effect of adjuvant bisphosphonates on nonsurgical periodontal
treatment: systematic review with meta-analyses
Abstract
To systemically review the literature about the use of bisphosphonates
(BP) as adjuvant to periodontal treatment. Three databased were searched
for randomized clinical trials that used any BP adjuvant to periodontal
treatment. Meta-analyses were performed for clinical attachment level
(CAL) and probing pocket depth (PPD). Subgroup analyses were considering
diabetes and smoking exposure. Thirteen studies were included. It was
showed mean difference (MD) of 1.52 mm (95%CI: 0.97–2.07) and 1.44 mm
(95%CI: 1.08–1.79) for PPD reduction and CAL gain, respectively, when
BP was locally delivered. Regarding the subgroup analysis, BP did not
provide significant improvement in smokers for PPD (MD: 1.35; 95%CI:
-0.13–2.83) and CAL (MD: 1.37; 95%CI: -0.17–2.91). The MD for
systemically administered BP was 0.40 mm (95%CI: 0.21–0.60) and 0.51
(95%CI: 0.19–0.83) for PPD and CAL, respectively. Additional clinical
effects of BP may be expected when administered with periodontal
therapy.