loading page

Baseline Characteristics and Outcomes of End-Stage Renal Disease Patients after In-hospital Sudden Cardiac Arrest: A National Perspective
  • +6
  • Muhammad Khan,
  • Moinuddin Syed,
  • Pratik Agrawal,
  • Mohammed Osman,
  • Muhammad Khan,
  • Anas Alharbi,
  • Mina Benjamin,
  • Sudarshan Balla,
  • Muhammad Bilal Munir
Muhammad Khan
West Virginia University Hospitals
Author Profile
Moinuddin Syed
West Virginia University School of Medicine
Author Profile
Pratik Agrawal
West Virginia University Hospitals
Author Profile
Mohammed Osman
West Virginia University Hospitals
Author Profile
Muhammad Khan
West Virginia University Hospitals
Author Profile
Anas Alharbi
West Virginia University Hospitals
Author Profile
Mina Benjamin
West Virginia University School of Medicine
Author Profile
Sudarshan Balla
West Virginia University Hospitals
Author Profile
Muhammad Bilal Munir
West Virginia University School of Medicine
Author Profile

Abstract

Background: End stage renal disease (ESRD) is a well-recognized risk factor for development of sudden cardiac arrest (SCA). There is limited data on baseline characteristics and outcomes after an in-hospital SCA event in ESRD patients. Methods: For the purpose of this study, data were obtained from National Inpatient Sample from January 2007 to December 2017. In-hospital SCA was identified using International Classification of Disease, 9th Revision, Clinical Modification and International Classification of Disease, 10th Revision, Clinical Modification codes of 99.60, 99.63 and 5A12012. ESRD patients were subsequently identified using codes of 585.6 and N18.6. Baseline characteristics and outcomes were compared among ESRD and non-ESRD patients in crude and propensity matched (PS) cohorts. Predictors of mortality in ESRD patients after an in-hospital SCA event were analyzed using a multivariate logistic regression model. Results: A total of 1,412,985 patients sustained in-hospital SCA during our study period. ESRD patients with in-hospital SCA were younger and had a higher burden of key co-morbidities. Mortality was similar in ESRD and non-ESRD patients in PS matched cohort (70.4% vs. 70.7%, p = 0.45) with an overall downward trend over our study years. Advanced age, Black race, diabetes, hypertension and peripheral vascular disease were independently associated with increased mortality in ESRD patients after an in-hospital SCA event. Conclusion: In the context of in-hospital SCA, mortality is similar in ESRD and non-ESRD patients in adjusted analysis. Adequate risk factor modification could further mitigate the risk of in-hospital SCA among ESRD patients.