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Making sense of virus size and the tradeoffs shaping viral fitness
  • Kyle Edwards,
  • Grieg Steward,
  • Christopher Schvarcz
Kyle Edwards
University of Hawai'i at Manoa
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Grieg Steward
University of Hawai'i at Manoa
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Christopher Schvarcz
University of Hawai'i at Manoa
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Abstract

Viruses span an impressive size range, with genome length varying a thousandfold and virion volume nearly a millionfold. For cellular organisms the scaling of traits with size is a pervasive influence on ecological processes, but whether size plays a central role in viral ecology is unknown. Here we focus on viruses of aquatic unicellular organisms, which exhibit the greatest known range of virus size. We develop and synthesize theory, and analyze data where available, to consider how size affects the primary components of viral fitness. We argue that larger viruses have fewer offspring per infection and slower contact rates with host cells, but a larger genome tends to increase infection efficiency, broaden host range, and potentially increase attachment success and decrease decay rate. These countervailing selective pressures may explain why a breadth of sizes exist and even coexist when infecting the same host populations. Oligotrophic ecosystems may be enriched in “giant” viruses, because environments with resource-limited phagotrophs at low concentrations may select for broader host range, better control of host metabolism, lower decay rate, and a physical size that mimics bacterial prey. Finally, we describe where further research is needed to understand the ecology and evolution of viral size diversity.

Peer review status:UNDER REVIEW

30 Apr 2020Submitted to Ecology Letters
04 May 2020Submission Checks Completed
04 May 2020Assigned to Editor
07 May 2020Reviewer(s) Assigned
23 Jun 2020Review(s) Completed, Editorial Evaluation Pending
26 Jun 2020Editorial Decision: Revise Major
06 Aug 20201st Revision Received
07 Aug 2020Submission Checks Completed
07 Aug 2020Assigned to Editor
09 Aug 2020Reviewer(s) Assigned
11 Sep 2020Review(s) Completed, Editorial Evaluation Pending