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Maternal and neonatal outcomes in COVID-19 infected pregnancies: a prospective cohort study
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  • Reihaneh Pirjani,
  • Reihaneh Hosseini,
  • Tahereh Soori,
  • Maryam Rabiei,
  • Ladan Hosseini,
  • Amene Abiri,
  • Ashraf Moini,
  • Arshia shizarpour,
  • Ghazal Razani,
  • Mahdi Sepidarkish
Reihaneh Pirjani
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Reihaneh Hosseini
Obstetrics and Gynecology Department, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran
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Tahereh Soori
Tehran University of Medical Sciences
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Maryam Rabiei
Obstetrics and Gynecology Department, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran
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Ladan Hosseini
Research development center, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran
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Amene Abiri
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Ashraf Moini
1Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR., Tehran, Iran 2Obstetrics and Gynecology Department, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran.
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Arshia shizarpour
Tehran University of Medical Sciences
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Ghazal Razani
Arak University of Medical Sciences
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Mahdi Sepidarkish
Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
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Abstract

Objective:To compare maternal and fetal consequences of Covid-19-infected pregnancies with non-infected pregnancies. Design: Prospective cohort study Setting: Iran Population: Pregnant women who were hospitalized from March 1 to April 20 2020 Methods: Participants were divided into three groups: Women with positive Covid-19 PCR test and/or positive CT scan findings in the presence of very typical clinical symptoms were classified as confirmed group,women with typical clinical symptoms along with two or more oflaboratory findings were classified as probable group and women who hadno clinical symptom of infection were classified as a control group.In order to minimize the presence of asymptomatic individuals in the control group, we used very precise exclusion criteria. Main Outcome Measures: Maternal, neonatal and pregnancy outcomes. Results:One hundred and eighty-two women enrolled including37 and 12 and 133 women inconfirmed, probable andcontrol groups respectively.Caesarean Section was carried outin total 96 women (52.74%,95%CI:45.22,68.31).Nosignificant association was found between COVID-19 infection and preterm labour(aRR:0.75,95%CI:0.30,1.87,P=0.546),low birth weight(aRR:1.15,95%CI:0.49,2.73,P=0.737), gestational diabetes(aRR:0.78,95%CI:0.26,2.33,P=0.669), preeclampsia (aRR:2.07,95%CI:0.50,8.47,P=0.310) intrauterine growth restriction(aRR:0.30, 95%CI:0.02,3.27,P= 0.327) preterm rupture of membrane(aRR:0.38,95%CI:0.04,3.30,P=0.383), stillbirth (aRR: 1.53,95%CI:0.15,14.71,P=0.712), postpartum haemorrhage (aRR:0.80,95%CI:0.11,5.57,P=0.829), neonatal intensive care unit admission (aRR:1.48,95%CI:0.38,5.78,P=0.568), neonatal sepsis(aRR:1.23,95%CI:0.68,2.20,P= 0.481) Conclusion:Given the effect of many potential factors, such as the severity of maternal infection, the time interval between the onset of symptoms in mother and childbirth, and many other factors on the effect of the virus on pregnancy outcomes, we suggest conductingmore extensive prospective studies in this field.

Peer review status:Published

05 Sep 2020Published in Journal of Travel Medicine. 10.1093/jtm/taaa158