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Clinical Findings and Predictors of Mortality in 354 COVID-19 Cases; a Report from a Tertiary Center in Tehran, Iran.
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  • Helia Mojtabavi,
  • Majid Sorouri,
  • Amir Kasaeian,
  • Bahar Saberzadeh-Ardestani ,
  • Amir Reza Radmard,
  • Bardia Khosravi,
  • Masoud Eslahi,
  • Azin Sirusbakht,
  • Seyed Mohammad Pourabbas,
  • Marjan Khodabakhshi,
  • Fatemeh Motamedi,
  • Fatemeh Azizi,
  • Zeynab Rajabi,
  • Leila Aghaghazvini,
  • Sara Naybandi Atashi,
  • Shahin Merat,
  • Ahmadreza Jamshidi,
  • Reza Malrkzadeh,
  • Alireza Sima,
  • Mohammad Abdollahi
Helia Mojtabavi
Tehran University of Medical Sciences
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Majid Sorouri
Tehran University of Medical Sciences
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Amir Kasaeian
Tehran University of Medical Sciences
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Bahar Saberzadeh-Ardestani
Tehran University of Medical Sciences
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Amir Reza Radmard
Tehran University of Medical Sciences
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Bardia Khosravi
Tehran University of Medical Sciences
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Masoud Eslahi
Tehran University of Medical Sciences
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Azin Sirusbakht
Tehran University of Medical Sciences
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Seyed Mohammad Pourabbas
Tehran University of Medical Sciences
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Marjan Khodabakhshi
Tehran University of Medical Sciences
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Fatemeh Motamedi
Tehran University of Medical Sciences
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Fatemeh Azizi
Tehran University of Medical Sciences
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Zeynab Rajabi
Tehran University of Medical Sciences
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Leila Aghaghazvini
Tehran University of Medical Sciences
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Sara Naybandi Atashi
Tehran University of Medical Sciences
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Shahin Merat
Tehran University of Medical Sciences
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Ahmadreza Jamshidi
Tehran University of Medical Sciences
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Reza Malrkzadeh
Tehran University of Medical Sciences
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Alireza Sima
Tehran University of Medical Sciences
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Mohammad Abdollahi
Tehran University of Medical Sciences
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Abstract

OBJECTIVE We reported the clinical characteristics, laboratory findings, and radiologic features of a COVID-19 registry in Iran and compared disease manifestations between the deceased patients and those who recovered. DESIGN This was a retrospective cross-sectional study with census sampling. SETTING Three hundred forty-five patients were enrolled from February 25th, 2020, to April 21st, 2020, in a tertiary referral hospital. PARTICIPANTS Patients with suggestive lung computed tomography scans (CT scans) who had respiratory symptoms and one of the followings: 1) loss of consciousness, 2) Respiratory rate more than 24, 3) pulse rate more than 90, 4) Systolic blood pressure less than 90 mmHg, 5) abnormal respiratory sounds, or 6) O2 saturation less than 93% or high-risk patients with respiratory symptoms or fever were enrolled to the study. MAIN OUTCOME MEASURES The primary outcome measures were days of hospital stay, any event of intubation, ICU admission, and in-hospital death. Logistic regression was done to assess the association between survival status and patients’ characteristics. RESULTS Nearly 45% of patients were older than 65 years, and 57.6% were male. Twenty hundred and sixty-five patients (74.8%) survived. Univariate analysis showed a significant association between mortality and older age, higher body mass index, aspartate transaminase, consciousness, cancer, organ transplant, oxygen saturation (SO2), systolic and diastolic blood pressure, body temperature, respiratory rate, pulse rate, anemia, leukocytosis, neutrophil to lymphocyte ratio (NLR), thrombocytopenia, creatinine, CRP, PH, PCO2, and bicarbonate. The relationship between mortality and consciousness, cancer, low SO2, tachycardia, platelet count less than 150,000 per microliter of blood, creatinine over 1.2 mg/dL remained statistically significant in multivariate analysis. The average total length of hospital stay was 5.98 days (SD: 5.87). CONCLUSION We observed that increased tachycardia, high-grade fever, tachypnea, and NLR strongly correlated with in-hospital death. In contrast, higher levels of systolic blood pressure had a protective role.