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The association of TNF related gene polymorphisms with scleritis in Chinese Han
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  • Peizeng Yang,
  • Yingnan Gao,
  • Liping Du,
  • Fuzhen Li ,
  • Jiadong Ding,
  • Geng Li,
  • Qingfeng Cao ,
  • Na Li,
  • Guannan Su,
  • Aize kijlstra
Peizeng Yang
The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair
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Yingnan Gao
The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair
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Liping Du
The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair
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Fuzhen Li
Zhengzhou University First Affiliated Hospital
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Jiadong Ding
The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair
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Geng Li
The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair
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Qingfeng Cao
The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing
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Na Li
The First Affiliated Hospital of Zhengzhou University; Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair
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Guannan Su
Chongqing Medical University First Affiliated Hospital
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Aize kijlstra
University Eye Clinic Maastricht, Maastricht, The Netherlands
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Abstract

Purpose: To examine the association of TNF related genes polymorphisms with scleritis in Chinese Han. Methods: A case-control study was carried out in 556 non-infectious scleritis patients and 742 healthy controls. A total of 28 SNPs were genotyped by the Sequenom MassArray® iPLEX GOLD Assay. Genotype and allele frequencies were compared between cases and healthy controls using the 2 or Fisher’s exact test, and P values were corrected using the Bonferroni correction method for multiple comparisons. Results: No significant association was observed between the individual SNPs in the TNF related genes and scleritis. Haplotype analysis showed a significantly decreased frequency of a TNFAIP3 CGT haplotype (order of SNPs: rs9494885, rs3799491, rs2230926) (Pc=0.021, OR=0.717, 95% CI=0.563–0.913), a significantly increased frequency of a TNFSF4 GT haplotype (order of SNPs: rs3850641, rs704840) (Pc=0.004, OR=1.691, 95% CI=1.205–2.372) and TNFSF15 CCC haplotype (order of SNPs: rs6478106, rs3810936, rs7865494) (Pc=0.012, OR=1.662, 95% CI=1.168–2.363) in scleritis patients compared to healthy controls. Conclusions: This study reveals that a three-SNP haplotype of the TNFAIP3 gene (CGT) may be a protective factor for the development of scleritis and that a two-SNP haplotype of the TNFSF4 gene (GT) and a three-SNP haplotype of the TNFSF15 gene (CCC) may be risk factors for scleritis in Chinese Han.