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Secondary Anaplastic Medulloblastoma in a Li-Fraumeni Syndrome patient with Primary Osteosarcoma
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  • Varun Gulati,
  • Bassem Razzouk,
  • Eric Beltz,
  • Catherine Socec
Varun Gulati
St Vincent
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Bassem Razzouk
Peyton Manning Children's Hospital
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Eric Beltz
Northwest Radiology Network PC 10603 North Meridian Street
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Catherine Socec
ameripath
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Abstract

Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome caused by germline TP53 mutation. Malignancies associated with LFS include osteosarcomas, leukemias, CNS, and adrenocortical tumors. While CNS tumors are common primary malignancies, we report the case of a pediatric patient with LFS who developed a never reported secondary anaplastic medulloblastoma.