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Craniospinal irradiation as a salvage treatment for metastatic relapsed DIPG
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  • Marta Perez-Somarriba,
  • Vicente Santa-María López ,
  • Ofelia Cruz Martinez,
  • Jordi Muchart,
  • Cinzia Lavarino,
  • Soraya Mico,
  • Andres Morales La Madrid
Marta Perez-Somarriba
Hospital Sant Joan de Deu
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Vicente Santa-María López
Hospital Sant Joan de Déu
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Ofelia Cruz Martinez
Hospital Sant Joan de Deu
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Jordi Muchart
Hospital Sant Joan de Deu
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Cinzia Lavarino
Hospital Sant Joan de Deu
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Soraya Mico
Hospital Vall d'Hebron
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Andres Morales La Madrid
Hospital Sant Joan de Deu
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Abstract

Diffuse intrinsic pontine glioma (DIPG) is the most frequent brainstem tumor in children. All therapeutic efforts are palliative, being focal irradiation the only therapy capable of reducing temporarily tumor volume. The vast majority of patients succumb to their disease during the first 2 years after diagnosis usually due to local progression. At first relapse, focal re-irradiation has shown to provide clinical and radiologic benefits. There are no reports of craniospinal irradiation (CSI) as a rescue regimen when progression is local and disseminated. We report a patient treated with CSI at metastatic progression showing clinical and radiological response with good tolerance.