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Renoprotective effects of extracellular vesicles: a systematic review
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  • Hossein Abbaszadeh,
  • Farzaneh Ghorbani,
  • Mehdi Talebi,
  • Mehdi Yousefi,
  • Ali Akbar Movassaghpour
Hossein Abbaszadeh
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Farzaneh Ghorbani
Tabriz University of Medical Sciences
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Mehdi Talebi
Tabriz University of Medical Sciences
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Mehdi Yousefi
Tabriz University of Medical Sciences
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Ali Akbar Movassaghpour
Tabriz University of Medical Sciences
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Abstract

Kidney diseases have recently become one of the major global health problems with high incidence and death risk. Extracellular vesicles (EVs), which are released from most cell types and human body fluids, have recently attracted extensive attention as the important carriers of protective cargos such as microRNAs and proteins that may contribute to promoted renal function. Therefore, we conducted this systematic review to investigate the renoprotective potential of EVs. We performed a comprehensive search of Medline (via PubMed), Embase, Cochrane and Proquest on August, 2019 for English papers. Of 2887 articles met the search criteria, 80 included in this systematic review and classified into several groups based on source of EVs. We then evaluated the EV research through screening their isolation method, size, marker, main effector, and potential mechanisms to induce renal protection. Taken together, EVs from various sources including mesenchymal stem cells, human liver stem cells, endothelial progenitor cells, endothelial colony-forming cells, serum and some other sources might have positive impacts on treatment of human kidney diseases in the future.

Peer review status:UNDER REVIEW

21 Aug 2020Submitted to International Journal of Clinical Practice
24 Aug 2020Assigned to Editor
24 Aug 2020Submission Checks Completed
31 Aug 2020Reviewer(s) Assigned