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SOLVENT OPTIMIZATION in the RECRYSTALLIZATION PURIFICATION of PHARMACEUTICAL PRODUCTS
  • Richard Fickelscherer
Richard Fickelscherer
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Abstract

Abstract: This treatment describes the details of a methodical three step algorithm for determining the optimal operating conditions for the recrystallization separations of solid mixtures. Our algorithm was applied to optimally separate a representative pharmaceutical product (Caffeine) from a related pharmaceutical product (Theophylline). The limitations of such calculations with currently available, widely used predictive methods for computing solution thermodynamics without experimental data are directly examined. Also presented here is a novel two stage recrystallization procedure which can potentially dramatically improve the recovery yields of the desired products. The systematic optimization calculations described herein should enable researchers to quickly screen many potential solvent systems and operating conditions and concentrate experimental efforts only on the most promising candidates for such purifications.

Peer review status:ACCEPTED

13 Aug 2020Submitted to AIChE Journal
31 Aug 2020Submission Checks Completed
31 Aug 2020Assigned to Editor
08 Sep 2020Reviewer(s) Assigned
21 Sep 2020Editorial Decision: Revise Major
29 Oct 20201st Revision Received
10 Nov 2020Assigned to Editor
10 Nov 2020Submission Checks Completed
13 Nov 2020Reviewer(s) Assigned
16 Nov 2020Editorial Decision: Revise Major
07 Dec 20202nd Revision Received
13 Dec 2020Submission Checks Completed
13 Dec 2020Assigned to Editor
14 Dec 2020Reviewer(s) Assigned
21 Dec 2020Editorial Decision: Accept