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Domino donor lymphocyte infusion for secondary poor graft function after HLA-mismatched allogeneic stem cell transplantation between HLA-identical sibling pairs with congenital immunodeficiency
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  • Satoru Hamada,
  • Taichi Uehara,
  • Jiro Miyamoto,
  • Shinobu Kiyuna,
  • Tokiko Oshiro,
  • Takeshi Yagi,
  • Shingo Kurokawa,
  • Nobuyuki Hyakuna,
  • Koichi Nakanishi
Satoru Hamada
Ryukyu Daigaku Igakubu Fuzoku Byoin
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Taichi Uehara
Ryukyu Daigaku Igakubu Fuzoku Byoin
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Jiro Miyamoto
Ryukyu Daigaku Igakubu Fuzoku Byoin
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Shinobu Kiyuna
Ryukyu Daigaku Igakubu Fuzoku Byoin
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Tokiko Oshiro
Ryukyu Daigaku Igakubu Fuzoku Byoin
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Takeshi Yagi
Ryukyu Daigaku Igakubu Fuzoku Byoin
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Shingo Kurokawa
Ryukyu Daigaku Igakubu Fuzoku Byoin
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Nobuyuki Hyakuna
Ryukyu Daigaku Igakubu Fuzoku Byoin
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Koichi Nakanishi
Ryukyu Daigaku Igakubu Fuzoku Byoin
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Abstract

Poor graft function (PGF) is a major obstacle to successful allogeneic stem cell transplantation after achieving normal bone marrow function. We report a successful treatment of domino DLI for poor graft function in younger brother with hyper IgM syndrome from HLA-identical elder brother with the same disorder with a history of HLA-mismatched unrelated bone marrow transplantation using same donor. Immunological profiling revealed that DLI-induced T-regulatory cells could correct skewed immune responses in the BM microenvironment due to secondary PGF pathogenesis. Immunological tolerized domino DLI can be a new therapeutic option for secondary PGF in HLA-identical sibling pairs with congenital immunodeficiency.