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The role of prognostic nutritional index in the management of pulmonary sarcomatoid carcinoma
  • wang yan,
  • Junfeng Liu,
  • Yu Cao
wang yan
Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital
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Junfeng Liu
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Introduction: Pulmonary sarcomatoid carcinoma is characterized by poor survival rates compared with other non-small cell lung cancer. Prognostic nutritional index has significant prognostic value in many malignant tumors. We conducted this retrospective study to investigate the role of prognostic nutritional index in patients with pulmonary sarcomatoid carcinoma and to determine prognostic factors. Methods: Of 8176 patients with resected lung cancer in a single high-volume institution between 2008 and 2015, 91 patients with pathologically diagnosed sarcomatoid carcinoma were included in our study and evaluated. Kaplan-Meier analysis and Cox regression analysis were conducted to analyze clinicopathologic data. Subgroup analysis of overall survival and recurrence-free survival among pulmonary sarcomatoid carcinoma patients were also conducted. Results: Univariate and multivariate analysis showed that, for OS, the pathological stage (HR: 2.464; 95%CI: 1.388-4.376; P=0.002) nodal metastasis (HR: 0.432; 95%CI: 0.201-0.927; P=0.031) and PNI (HR: 0.102; 95%CI: 0.050-0.207; P<0.001) were independent prognostic factors. And for RFS, We found PNI as an independent prognostic factor (HR: 0.078; 95% CI, 0.036–0.169; P<0.001), along with nodal metastasis (HR: 0.418; 95%CI, 0.193-0.906; P=0.027) and the pathological stage (HR: 2.448; 95%CI, 1.364-4.393; P=0.003). In the subgroup of patients with PNI≥49.4, univariate analysis showed treatment modality was a significant factor of overall survival (P=0.001); multivariate analysis showed patients received postoperative chemotherapy (HR: 0.288; 95%CI, 0.095-0.874; P=0.028) or postoperative chemotherapy with targeted therapy (HR: 0.148; 95%CI, 0.030-0.726; P=0.019) has better overall survival rates. Conclusion: The PNI and the pathological TNM stage are independent prognostic factors for pulmonary sarcomatoid carcinoma. PNI is an important indicator for the selection of postoperative adjuvant therapy. Patients with PNI ≥ 49.4 may benefit from postoperative chemotherapy and targeted therapy. We still need further prospective studies to confirm these results