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Aspergillus but Not Candida: Fatal Fungus Infection in Critical COVID-19 Patients
  • +14
  • Aifang Zhong,
  • Yang Yang,
  • Jiang Wu,
  • Lei Xiong,
  • Jian Wu,
  • Jiawei Shen,
  • Wei Dai,
  • Tao Luo,
  • Yanju Guo,
  • Jun Zhao,
  • Ying Han,
  • Peiran Zhu,
  • Qiuyue Wu,
  • Weiwei Li,
  • Changjun Wang,
  • Li Han,
  • Xinyi Xia
Aifang Zhong
Nanjing Jinling Hospital
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Yang Yang
Nanjing Jinling Hospital
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Jiang Wu
Nanjing Jinling Hospital
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Lei Xiong
Nanjing Jinling Hospital
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Jian Wu
Nanjing Jinling Hospital
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Jiawei Shen
Nanjing Jinling Hospital
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Wei Dai
Nanjing Jinling Hospital
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Tao Luo
Nanjing Jinling Hospital
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Yanju Guo
Nanjing Jinling Hospital
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Jun Zhao
Nanjing Jinling Hospital
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Ying Han
Nanjing Jinling Hospital
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Peiran Zhu
Nanjing Jinling Hospital
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Qiuyue Wu
Nanjing Jinling Hospital
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Weiwei Li
Nanjing Jinling Hospital
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Changjun Wang
Center for Disease Control and Prevention of PLA
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Li Han
Center for Disease Control and Prevention of PLA
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Xinyi Xia
Nanjing Jinling Hospital
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Abstract

Abstract Objectives: Earlier researches suggested patients should be routinely screened for bacteria and fungi infection after COVID-19 being confirmed. Here, we enrolled 236 patients with COVID-19 to analyze the clinical characteristics, fungal strains, mortality, and laboratory data of different groups. Design: Single center retrospective study Patients: A total of 236 COVID-19 patients from Huoshenshan Hospital were included in this study, consisting of 14(6%) died cases, 222(94%) discharged cases . Results: The result revealed that 5 mortality in positive group were all related to aspergillus infection while candida infection rarely caused death. Aspergillus was most common in non-survivors while candida was most common in survivors. In terms of interleukin-6 (IL6), viral loads, nucleic acid clearance time, etc, fungal serologically positive group had a higher level than negative group. Conclusions: Non-survivors of Covid-19 with fungal infection were almost associated with aspergillus infection. Aspergillus infection, instead of candida infection might be fatal for critical ill patients with COVID-19. There is great significance to carry out routine screening for fungal infection especially for critical patients to enable early treatment to be implemented. Keywords: coronavirus disease 2019 (COVID-19); fungal infection; aspergillus; mortality