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THE EFFECTS OF VITAMIN B12, VITAMIN D, FERRITIN LEVEL, NEUTROPHIL/MONOCYTE RATIO AND SOME BLOOD PARAMETERS ON GENITAL WARTS PRESENCE, THE NUMBER OF LESIONS, AND RECURRENCE
  • Aslan Demir,
  • Semih Guder
Aslan Demir
Bezmialem Foundation University Medical Faculty Hospital
Author Profile
Semih Guder
Bezmialem Foundation University Medical Faculty Hospital
Author Profile

Abstract

Objective Human Papillomavirus (HPV) that is an epitheliotropic virus that infects basal keratinocytes on epithelia of skin and mucosal membranes has been isolated in genital warts (GWs). The relationships between cancer caused by HPV and some vitamins such as B12 and vitamin D and iron metabolism, as well as leukocytes and their ratios have been investigated in the literature. Our aim is to evaluate these relatioships at the level of GW as well as to analyse if there is a relationship between the investigated parameters and lesion numbers. Materials and Methods Data were obtained from 98 and 94 patients for group 1 and 2, including GW patients and healthy people, respectively. The blood parameters and lesion numbers in the GW patients were reported and analysed in terms of vitamin B12 and D, ferritin and leucocytes. Results A correlation was established between lesion numbers, age and midcorpusculer volume (MCV) (p<0.05). There was no any correlation between lesion numbers and recurrent cases. According to the comparative analysis, there were a difference in terms of ferritin, neutrophil, monocyte, hemoglobine, MCV and neutrophil/monocyte ratio between groups. The cutoff values for neutrophil, monocyte and N/M ratios were 56.45, 4.91, and 7.825, respectively Conclusion While our study showed that GW development may be affected by blood ferritin levels and in this situation, MCV, neutrophil, monocyte and N / M ratios may change, a relation was found between lesion numbers and age and mean MCV values only. However, further studies are needed to clarify this issue.

Peer review status:Published

May 2021Published in Andrologia volume 53 issue 4. 10.1111/and.14006