Abstract
Introduction: The aim of our study is to determine whether insulin
resistance has any effect on pancreatic exocrine function in people with
insulin resistance. Method: The study included 43 insulin resistant
cases with HOMA-IR≥2.5 and 43 controls (HOMA-IR <2.5.) without
any disease, pregnancy. Fasting blood glucose, insulin, HbA1c, total
cholesterol, triglyceride, HDL, LDL, creatinine, ALT, AST, Adiponectin,
Leptin, pancreatic amylase, lipase were studied in both groups. Results:
Statistically, both groups were similar in respect to gender and age (p:
0.25, 0.11, respectively). Body Mass Index were significantly higher in
the case group (p 0.00). Fecal Elastase-1 levels were significantly
lower in the IR group (p: 0.00). Blood glucose, insulin and HbA1c levels
were significantly higher in the IR group than in the control (p: 0.00,
0.00, 0.00, respectively). Leptin levels were significantly higher in
the IR group compared to the controls (p: 0.01). In the Pearson
correlation analysis in the group with insulin resistance, a significant
positive relation (p: 0.022 r: +0.34) was detected between HOMA-IR and
Adiponectin. There was a significant negative relation between
pancreatic amylase and HOMA-IR (p: 0.029, r: -0.33), a significant
negative relation between Fecal Elastase-1 and Adiponectin (p: 0.038, r:
-0.31), a significant positive relation between Leptin and Adiponectin
(p : 0.00, r: 0.59). Conclusion: Fecal Elastase -1 level decreased
markedly in patients with insulin resistance, showing pancreatic
exocrine dysfunction.