Successful use of recombinant activated factor VII administered via
automated bolus pump following emergency laparoscopic appendectomy in a
patient with mild congenital FVII deficiency: Case report
Surgery in patients with factor VII (FVII) deficiency may be complicated
by severe bleeding, requiring regular bolus doses of replacement
therapy. Eptacog alfa (activated) is a recombinant activated FVII
(rFVIIa) used for the treatment of bleeds and perioperative management
in patients with approved bleeding disorders, including FVII deficiency.
We report that using the B-Braun Perfusor® Space syringe pump to
automatically deliver regular bolus rFVIIa doses provided effective
hemostasis and no safety concerns in a patient with mild FVII deficiency
undergoing emergency laparoscopic appendectomy. Additional benefits
included saving nursing/hospital resources, reducing treatment burden
and reassurance for the patient/family, and healthcare providers.