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Celastrol alleviates comorbid obesity and depression by directly binding amygdala hnRNPA1 in a mouse model
  • +7
  • Chunyan Zhu,
  • Jun Yang,
  • Yongping Zhu,
  • Jiahao Li,
  • Hongyu Chi,
  • Congmin Tian,
  • Yuqing Meng,
  • Yanqing Liu,
  • Jigang Wang,
  • Na Lin
Chunyan Zhu
China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica
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Jun Yang
China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica
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Yongping Zhu
China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica
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Jiahao Li
China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica
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Hongyu Chi
China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica
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Congmin Tian
China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica
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Yuqing Meng
China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica
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Yanqing Liu
China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica
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Jigang Wang
China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica
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Na Lin
China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica
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Abstract

Background and Purpose: Obesity and depression are highly comorbid and far from effective treating. Celastrol was reported useful for obesity, but its role in the obesity-depression comorbidity remains unknown. This study aims to investigate the efficacy and associated mechanism of celastrol in this comorbidity.