loading page

Anxiety And Depressive Effects Of Antiepileptics In Animal Models
  • +1
  • Yasemin Karal,
  • Mehmet Azizoğlu,
  • Çetin Hakan Karadağ,
  • Serap Tevhide Karasalihoğlu
Yasemin Karal
Trakya Üniversitesi Tıp Fakültesi
Author Profile
Mehmet Azizoğlu
Kocaeli Üniversitesi Tıp Fakültesi
Author Profile
Çetin Hakan Karadağ
Trakya Üniversitesi Tıp Fakültesi
Author Profile
Serap Tevhide Karasalihoğlu
Trakya Üniversitesi Tıp Fakültesi
Author Profile

Abstract

Aim: Cognitive impairment is frequently observed in epileptic patients. It has been seen that not only epilepsy but antiepileptic drugs also impair cognitive functions. The present study was undertaken to assess the effect of three anticonvulsants Levetiracetam (60 mg/kg, p.o.), Vigabatrin (100 mg/kg, p.o.) and Sodyum Valproat (50 mg/kg, p.o.) on anxiety and depression on animal models of rats. Materials and methods: Elevated plus maze (EPM) and Forced swimming test- Porsolt tests (FST) were carried out after 12th weeks of the lifes of rats those that took the three anticonvülsion therapy administration. Results: The results of the present study indicate that none of the three antikonvülsan drugs taken in childhood period impairs anxiety and depression in adult hood. Conclusion: To conclude, long term administration of Levetiracetam, Vigabatrin and Sodyum Valproat have no effect on the anxiety and depression at adulthood time if epilepsy does not exist.