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Do CRP Levels Predict Severity in COVID-19 Hospitalized Egyptian Patients?
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  • Shaimaa Fouad,
  • Mohamed Allam,
  • Sara Taha,
  • Ahmed Okba,
  • Sylvia Roman,
  • Amr Hosny,
  • Mayada Moneer
Shaimaa Fouad
Ain Shams University Faculty of Medicine
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Mohamed Allam
Ain Shams University Faculty of Medicine
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Sara Taha
Ain Shams University Faculty of Medicine
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Ahmed Okba
Ain Shams University Faculty of Medicine
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Sylvia Roman
Ain Shams University Faculty of Medicine
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Amr Hosny
Ain Shams University Faculty of Medicine
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Mayada Moneer
Ain Shams University Faculty of Medicine
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Abstract

Background Coronavirus disease 2019 (COVID-19), has affected countless countries all over the world with rapidly increasing case fatality reports and a highly variable clinical course. Since the evolution of the clinical condition of these patients is difficult to forecast, early identification of prognostic indicators is an essential foundation to regulate treatment plans and promptly identify the severity of patients’ conditions. Aim: To assess the correlation between CRP level on admission with the severity of the COVID-19, the risk for ICU admission and the findings in CT chest Method A retrospective cohort study where the clinical data of 276 patients with laboratory-confirmed COVID-19 infection were collected from El Obour Ain Shams University Specialized Hospital for Isolation records on admission from April 10, 2020 till July 30, 2020. Results Fever was the most common presenting symptom (total number 135; 41.7%), followed by cough (total number 133; 41.2%). High CRP levels were predictive of higher COVID-19 severity and ICU admission (p=0.000). Likewise, CRP levels were higher in patients with more chest affection as denoted by the CT chest findings (p=0.000). Conclusion Serum CRP is a simple and effective prognosticator which casts light on potentially critical patients. Consequently, it can be used to reduce the mortality of patients. Keywords: COVID-19, Hospital, CRP, ICU, severity.

Peer review status:UNDER REVIEW

21 Jan 2021Submitted to International Journal of Clinical Practice
22 Jan 2021Submission Checks Completed
22 Jan 2021Assigned to Editor
01 Feb 2021Reviewer(s) Assigned
22 Apr 2021Review(s) Completed, Editorial Evaluation Pending
02 May 20211st Revision Received
07 May 2021Submission Checks Completed
07 May 2021Assigned to Editor
07 May 2021Review(s) Completed, Editorial Evaluation Pending
24 May 2021Reviewer(s) Assigned