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Development of a continuous evaporation system for an API solution stream prior to crystallization
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  • Phillip Roche,
  • Roderick Jones,
  • Brian Glennon,
  • Philip Donnellan
Phillip Roche
University College Dublin
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Roderick Jones
University College Dublin
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Brian Glennon
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Philip Donnellan
University College Dublin
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Abstract

A bubble column was investigated as a method to achieve a desired and controllable rate of evaporation of a pharmaceutical solution in continuous processing mode. Applying a developed thermodynamic model to predict the rate of evaporation, all predicted values achieved accuracies within the bounds of instrumentation errors. The model accounted for the measured effect of reduced vapor pressure caused by dissolved solids as a function of their concentration. A general method to obtain accurate measurement of this effect is introduced and applied, improving the accuracy of model predictions. Predicting the rate of evaporation using the developed model, consistent and repeatable evaporation rates ranging from 0.7–6.9 g/min were achieved. Applying the column as a controllable evaporator, the concentration of a dilute feed stream was increased in a single equilibrium stage and coupled to a crystallizer. The configured system achieved a steady state of controllable operation over a duration of 5 hours

Peer review status:UNDER REVIEW

13 Jan 2021Submitted to AIChE Journal
20 Jan 2021Submission Checks Completed
20 Jan 2021Assigned to Editor
01 Feb 2021Reviewer(s) Assigned
04 May 2021Editorial Decision: Revise Major
07 Jun 20211st Revision Received
16 Jun 2021Submission Checks Completed
16 Jun 2021Assigned to Editor
16 Jun 2021Reviewer(s) Assigned